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→RTS, S/AS01
**anti-CSP Ab titers wane
**White, Lancet Inf. Dis., 2015;15(12)1450-8
===AMA1-withdrawn===
*no efficacy for overall
*ad hoc analysis: 64.3% efficacy against a specific ''Plasmodium'' polymorphism, AMA1 3D7 DNA sequence
**clinically meaningless because of many polymorphism
===Pvs25-withdrawn===
*antigen: Pvs25H expressed in ''S. cerevisiae''
*adjuvant: alhydrogel, ISA51
**not enough antibody induction or serious side effects at phase 1
==症状==
