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*>86% reduction
*high concentration in genital issues
*Administration options
#daily - for anal and vaginal sex
#event-based - for anal sex
#≧4 doses/week - anal sex
===daily===
*1 tablet/day
*effective for anal sex 1 day after of commencement
*effective for vaginal sex 7 days after of commencement
===event-based===
*2 tabltes at 2-24 hours before anal sex + 1 tablet 24-48 hours after the sex
*not effective against vaginal sex
===4 doses/week===
===how to stop===
*have to continue for a certain duration after the last sex
*
*
===monitoring===
*test renal function every 3 mo
**annually for eGFR>90 or <40y/o
*test bone history
*test HIV, hepB, Urea, Electrolytes
*U/A
*offer STIs screening
===contraindication===
*Renal dysfunction
*Osteoprorosis
*event-based dosing is option for contraindicated people
===clincal trial===
*PROUD study
**86% reduction of HIV
*IMPACT study
==治療==
