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ページの作成:「==epidemiology== *endemic >150 countries *55,000 deaths/year **mostly children in Asia and Africa **mainly in rural areas *most endemic in India followed by Bangladesh an…」
==epidemiology==
*endemic >150 countries
*55,000 deaths/year
**mostly children in Asia and Africa
**mainly in rural areas
*most endemic in India followed by Bangladesh and China as well as Pakistan
*Latin "rabere" = to rage, to rave
*Sanskrit "rabhas" = to do violence
==pathogen==
*family ''Rhabdoviridiae'', genus ''Lyssavirus''
**Rabies lyssavirus
**Duvenhage lyssavirus
**European bat lyssavirus
*negative polarity, monostrand RNA virus
*enveloped
*5 component proteins
**N, P, M, G, L
**G (glycoprotein) is ligand to cellular invasion
***target of vaccine
**human receptor: nAChR, NCAM, p75NTR - all developed only in nerve cells
==responsible animals==
*domestic animal - dog, cat in Asia and Africa
*wildlife - bat, fox, raccoon, coyote in Europe and Americas
*''Lyssavirus'' circulates within a same animal species
**sometimes transmitted to other species - "spillover" phenomenon
*endemic >150 countries
*55,000 deaths/year
**mostly children in Asia and Africa
**mainly in rural areas
*most endemic in India followed by Bangladesh and China as well as Pakistan
*Latin "rabere" = to rage, to rave
*Sanskrit "rabhas" = to do violence
==pathogen==
*family ''Rhabdoviridiae'', genus ''Lyssavirus''
**Rabies lyssavirus
**Duvenhage lyssavirus
**European bat lyssavirus
*negative polarity, monostrand RNA virus
*enveloped
*5 component proteins
**N, P, M, G, L
**G (glycoprotein) is ligand to cellular invasion
***target of vaccine
**human receptor: nAChR, NCAM, p75NTR - all developed only in nerve cells
==responsible animals==
*domestic animal - dog, cat in Asia and Africa
*wildlife - bat, fox, raccoon, coyote in Europe and Americas
*''Lyssavirus'' circulates within a same animal species
**sometimes transmitted to other species - "spillover" phenomenon
