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*sleeping sickness
→Define the clinical stage of rhodesiense
==African trypanosomiasis==
*Sleeping sickness {|class="wikitable" style="width:800px900px"
|-
!
!style="width:4030%"|''Trypanosoma brucei gambiense''!style="width:4030%"|''Trypanosoma burcei rhodesiense''!style="width:30%"|''Trypanosoma brucei brucei''
|-
!Distribution
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*West Africa
**Broader area of West Africa to the west of Great Rift Valley
**In 24 countries
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**Limited to the east of Great Rift Valley
**In 13 countries
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*Trypanosomiasis of stock and wild animals
**Called as "Nagana"
|-
!Vector
**Savannah
*Mainly bite animals
|
|-
!Infectivity
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*Mainly infect to human
*Adapted to human, leading to relatively slow and mild disease progression compared to ''rhodesiense''
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*adapted Mainly infect to animals**Adapted to animals, leading to relatively rapid progress of disease|*
|-
!Human infection
*Acute infection
*Incubation weeks to months
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*No human case
|}
===''Trypanosoma brucei brucei''===*Trypanosomiasis of stock and wild animals**"Nagana"*no human infection ===pathogenesis=Pathogenesis==
#trypanosomal chancre after tsetse fly bite
#acute hemolymphatic stage
*more acute by ''T. brucei rhodesiense'', slower by ''T. brucei gambiense''
===diagnosis=Diagnosis==
*serology
**card agglutination test for trypanosomiasis (CATT)
**wet praparation for motile trypanosoma
**Giemsa stain (with fixed)
====define Define the clinical stage of ''T. b. rhodesiense''====
*lumbar puncture
**CSF WBC > 5 cell/mm<sup>3</sup> stage 2
===treatment=Treatment==
*should commence in earlier stage
**difficult to treat in CNS involvement
