「Dermatological mycobacterium infecions」の版間の差分

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==leprosy==
 
==leprosy==
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*manifests in skin and peripheral nerves
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*papule, macule, plaque, hypopigmentation, nodule
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*loss of sensation, paralysis, amyotrophy
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*incubation months to >30 years
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 +
===Ridley-Jopling classification===
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*TT - tuberculoid
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*BT - borderline tuberculoid
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*BB - borderline borderline
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*BL - borderline lepromatous
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*LL - lepromatous
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*TT direction - abnormal or significant immune response (granulomatous) against few ''M. leprae'' bacilli
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**PB in WHO classification
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**infiltrated plaque
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**well-defined, sharp border
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**single skin lesion
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**localized, asymmetrical
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**loss of sensation at skin lesion
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***in histopathology nerves are surrounded by granuloma
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*LL direction - least cellular immunity or allergic reaction against much amount of ''M. leprae'' bacilli
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**MB in WHO classification
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**macule, papule, nodule
 +
**
  
 
==cutaneous TB==
 
==cutaneous TB==

2021年4月22日 (木) 09:35時点における版

skin mycobacterial diseases

  • leprosy
    • only in human
  • cutaneous TB
    • only in human
  • non-TB mycobacterium (NTM)
    • water-borne
    • M. ulcerans = Buruli ulcer
    • M. chelonae
    • M. marinum - highest incidence
    • M. avium - long-maintained hot bath

when to suspect

  • skin symptoms without inflammatory sings (pain, swelling, redness)
  • slow progression
  • specific patient background
    • occupation, living place, triggering event

leprosy

  • manifests in skin and peripheral nerves
  • papule, macule, plaque, hypopigmentation, nodule
  • loss of sensation, paralysis, amyotrophy
  • incubation months to >30 years

Ridley-Jopling classification

  • TT - tuberculoid
  • BT - borderline tuberculoid
  • BB - borderline borderline
  • BL - borderline lepromatous
  • LL - lepromatous
  • TT direction - abnormal or significant immune response (granulomatous) against few M. leprae bacilli
    • PB in WHO classification
    • infiltrated plaque
    • well-defined, sharp border
    • single skin lesion
    • localized, asymmetrical
    • loss of sensation at skin lesion
      • in histopathology nerves are surrounded by granuloma
  • LL direction - least cellular immunity or allergic reaction against much amount of M. leprae bacilli
    • MB in WHO classification
    • macule, papule, nodule

cutaneous TB

  • estimated 1-2% of all TB patients
  • diverse range of symptoms

route of transmission

  • exogenous inoculation
    • ulcer,
    • tuberculosis verrucosa cutis, warty tuberculosis
    • orificial tuberculosis - direct contact of M.t. contained in sputum from pulmonary TB
  • endogenous spread from internal TB
    • abscess,
    • scrofuloderma - emerged from lymphadenitis
  • hematogenous
    • nodule, abscess, patch
    • as part of miliary tuberculosis
    • immunocompromised host, children
  • tuberculid - allergic reaction against M. tuberculosis
    • erythema, papule
    • in immunocompetent patient
    • skin biopsy of the eruption shows no bacteria
    • strong positivity of Mantoux test
    • Bazin erythema
      • usually localized to lower legs

treatment

  • same as of systemic tuberculosis

skin NTM