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*malaria does not cause IDA directly; destruction of RBCs by ''Plasmodium'' does not cause iron loss
**anemia by malaria is mainly by inflammation, which suppresses iron absorption
==sickle cell anemia==
*monogenetic recessive disorder
*hemoglobin mutation
*HbA mutated into HbS (sickle cell trait) or HbC (West Africa)
*sickle cell trait protect against death from severe malaria
**not prevent infection itself
===clinical picture of SCD===
*affects all organ systems
*disease pattern and severity varies very much on patients
===chronic management===
*first to identify high risk groups
==thalassemia==
*decreased hemoglobin production
**sickle cell trait is problem of hemoglobin destruction
*beta thalassemia affects beta chain of hemoglobin
*alpha thalassemia affects alpha chain of hemoglobin
*major, media, minor
