「Correlates of Protection」の版間の差分

2022年10月22日 (土) 13:28時点における版

Definitions of terms
Correlates of Protection (CoP)	An immune response statistically correlated with protection
Mechanistic CoP (mCoP)	An immune response responsible for protection
Non-mechanistic CoP (nCoP)	An immune response surrogating mCoP and easily measured

Theoretically
- To measure immune responses at the time of exposure to the infection and compare them between those who get infection and not
Practically
- To measure immune responses after the vaccination and compare them between those who get infection and not
  - usually done in vaccine clinical trial phase 3
- To measure immune responses at the time of challenging exposure of vaccinated volunteers
  - would be ethically approved only for milder and/or treatable infections such as seasonal influenza, cholera, dengue or cytomegalovirus
- To extrapolate vaccinated animal challenge model
- To extrapolate protective level of dosing of passive immunization (antibody treatment)

@@ 12行目: / 12行目: @@
 |An immune response surrogating mCoP and easily measured
 |}
+===Identifying method of CoP (mCoP)===
+*Theoretically
+**To measure immune responses '''at the time of exposure to the infection''' and compare them between those who get infection and not
+*Practically
+**To measure immune responses '''after the vaccination''' and compare them between those who get infection and not
+***usually done in vaccine clinical trial phase 3
+**To measure immune responses '''at the time of challenging exposure of vaccinated volunteers'''
+***would be ethically approved only for milder and/or treatable infections such as seasonal influenza, cholera, dengue or cytomegalovirus
+**To extrapolate vaccinated animal challenge model
+**To extrapolate protective level of dosing of passive immunization (antibody treatment)