「Dermatology in the tropics」の版間の差分
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Vaccipedia.admin (トーク | 投稿記録) (ページの作成:「==NTDs== *preventative chemoTx and transmission control (PCT) ones **mass drug administration ***onchocerciasis ***lympahatic filariasis ***schistosomiasis ***soil-transm…」) |
Vaccipedia.admin (トーク | 投稿記録) |
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| 31行目: | 31行目: | ||
*respiratory transmission? difficult to determine because of long incubation period | *respiratory transmission? difficult to determine because of long incubation period | ||
*skin + peripheral nerve manifestation | *skin + peripheral nerve manifestation | ||
| + | **''M. leprae'' has affinity to Schwann cells and destroy them | ||
*clinical manifestation differs in wide range depending on amount of bacilli and host immune response | *clinical manifestation differs in wide range depending on amount of bacilli and host immune response | ||
*WHO classification | *WHO classification | ||
| 45行目: | 46行目: | ||
**BL | **BL | ||
**LL | **LL | ||
| + | *delay of Dx and Tx leads to long term disability and deformity resulted in stigma and discrimination | ||
| + | |||
| + | ==Buruli ulcer== | ||
| + | *''Mycobacterium ulcerans'' | ||
| + | *75% of worldwide patients are in Ivory Coast, Ghana and Benin | ||
| + | **rarely found in Japan and Australia (esp. in Victoria) | ||
| + | *transmission route unknown | ||
| + | **patients are often in proximity of stagnant water body | ||
| + | *undermined wound edges, thick necrotic tissue, pain is liminited | ||
| + | *3 months course | ||
| + | #subcutaneous nodules | ||
| + | #plaque | ||
| + | #edema - develops pain | ||
| + | #ulcer | ||
| + | *lipid toxin produced and secreted by ''M. ulcerans'' is pathogenetic | ||
| + | **highly hydrophobic | ||
| + | **''M. ulcerans'' itself is not pathogenetic | ||
2021年4月21日 (水) 09:39時点における版
NTDs
- preventative chemoTx and transmission control (PCT) ones
- mass drug administration
- onchocerciasis
- lympahatic filariasis
- schistosomiasis
- soil-transmitted helminths
- mass drug administration
- innovative and intensified disease management (IDM) ones
- individual care findings and case management
- leishmaniasis
- buruli ulcer
- mycetoma
- yaws
- azithromycin is turning yaws to PCT
- scabies
- ivermectin is turning scabies to PCT
- ...
- individual care findings and case management
skin NTDs
- new movement to integrate disease controls between NTDs that manifest with skin symptoms
- led by WHO and community dermatologists
exanthematology
- morphology of each rash
- distribution
leprosy
- Mycobacterium leprae
- 20,000-25,000 new cases/year
- mostly in India
- respiratory transmission? difficult to determine because of long incubation period
- skin + peripheral nerve manifestation
- M. leprae has affinity to Schwann cells and destroy them
- clinical manifestation differs in wide range depending on amount of bacilli and host immune response
- WHO classification
- MB - multibacillary > 5 lesions
- multi-drug Tx for 1 year
- PB - paucibacillary 2-5 lesions
- multi-drug Tx for 6 months
- single lesion
- single dose
- MB - multibacillary > 5 lesions
- Rideley & Jpling classification
- TT
- BT
- BB
- BL
- LL
- delay of Dx and Tx leads to long term disability and deformity resulted in stigma and discrimination
Buruli ulcer
- Mycobacterium ulcerans
- 75% of worldwide patients are in Ivory Coast, Ghana and Benin
- rarely found in Japan and Australia (esp. in Victoria)
- transmission route unknown
- patients are often in proximity of stagnant water body
- undermined wound edges, thick necrotic tissue, pain is liminited
- 3 months course
- subcutaneous nodules
- plaque
- edema - develops pain
- ulcer
- lipid toxin produced and secreted by M. ulcerans is pathogenetic
- highly hydrophobic
- M. ulcerans itself is not pathogenetic
