「Giardiasis」の版間の差分
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| 15行目: | 15行目: | ||
*hutch in intestinal wall into trophozoite | *hutch in intestinal wall into trophozoite | ||
*trophozoite propagets in binary fission | *trophozoite propagets in binary fission | ||
| − | *trophozoite does not invade human cells, just | + | *trophozoite does not invade human cells, just adhere to intestinal mucosa (villi) |
**produces no bloody diarrhea | **produces no bloody diarrhea | ||
*trophozoite transforms into cyst under dry environment | *trophozoite transforms into cyst under dry environment | ||
| 31行目: | 31行目: | ||
*abrupt onset of diarrhea | *abrupt onset of diarrhea | ||
*abd cramps | *abd cramps | ||
| + | *no fatality case | ||
===diagnosis=== | ===diagnosis=== | ||
| 41行目: | 42行目: | ||
**EIA - rapid diagnostic test | **EIA - rapid diagnostic test | ||
*fluorescence microscopy of feces | *fluorescence microscopy of feces | ||
| + | |||
| + | ===treatment=== | ||
| + | *metronidazole | ||
2021年4月27日 (火) 11:00時点における版
目次
Giardia intestinalis
- a.k.a. G. lamblia or G. duodenalis
- 「ランブル鞭毛虫」is named after G. lamblia
epidemiology
- worldwide
- human is main reservior
- beaver in North America
- water-borne
- food-borne thru uncooked vegetable or fruit washed with contaminated water
- feco-oral
life cycle
- ingestion of cyst
- hutch in intestinal wall into trophozoite
- trophozoite propagets in binary fission
- trophozoite does not invade human cells, just adhere to intestinal mucosa (villi)
- produces no bloody diarrhea
- trophozoite transforms into cyst under dry environment
- cyst is resistant to chlorinated water
morphology
- 2 nuclei in trophozoite
- 4 nuclei in cyst
clinical features
- incubation 3 days to months
- 10 cysts are enough to develop symptoms
- most asymptomatic
- repeated infections induce immunity
- abrupt onset of diarrhea
- abd cramps
- no fatality case
diagnosis
- fecal microscopy
- duodenal fluid aspiration
- "String test"
- "Crosby capsule"
- antigen detection in feces
- ELISA
- EIA - rapid diagnostic test
- fluorescence microscopy of feces
treatment
- metronidazole
