HIV-TB co-infection
risk of TB even at high CD4 count
- CD4 cell depletion
- TB-specific T cell↓
TB exacerbates HIV infection
- increase HIV replication in TB granuloma
ART significantly reduces TB incidence
drug interaction
- RFP induces CYP
- RFP accelerates metabolism of PI, some NNRTI and INI
IRIS
- major criterion
- active TB < 3 months of initiation of ART
- minor criteria
