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==epidemiology==
*70-500 mil. infections per year
**genotype of dengue virus
**co-morbidity
*organ impairment is due to both of direct cell destruction by virus and secondary inflammatory process like plasma leakage
**some patients present virus encephalitis, the others encephalopathy without virus in CSF
==treatment==
*RCTs of antivirals and steroid have shown no effect so far
===algorithm of fluid management===
