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、 2021年4月27日 (火) 11:21
==''Cryptosporidium'' spp.==
*especially ''C. paravum'', ''C. hominis''
===epidemiology===
*worldwide
*2nd important pathogen for moderate-severe diarrhea before 1 year of life
===life cycle===
*calf is reservoir of ''C. hominis''
*resistant to chlorinated water
*auto-infection in host intestine
*survive >1 year in 4-6℃ cold water
*vulnerable to dry environment
*human excretes 100 mil. cysts per day
*calf excretes 10 bil. cysts per day
===morphology===
*oocyst contains 4 sporozoites
===clinical features===
*incubation 1-12 days
*symptoms 1-2 weeks
*watery diarrhea
*abd cramps
*bloating
*fever, malaise
*weight loss
*often self-limiting
*problemable in children in developing countries, immunocompromised
===diagnosis===
*fecal microscopy
**Ziehl-Neelsen stain
**Auramine stain
===treatment===
*nitazoxianide
*paromomycin