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→prescribing antimicrobials for children and pregnant women
==prescribing antimicrobials for children and pregnant women==
===children===
*first line empiric antimicrobials for neonatal sepsis:
**ampicillin and gentamycin
**but in fact AMPC/GM or CTX/GM doesn't cover well neonatal sepsis pathogens now.... meropenem might be the best
*dose varies not depending on weight but also on age, especially in neonates and preterm babies, because of differences of absorption, distribution, metabolism and excretion
===pregnancy===
====malaria in pregnancy====
*risk for severe malaria
*maternal anemia
*spontaneous abortion/stillbirth
*premature birth/LBW
*treament
**severe malaria in pregnancy - artesunate IV
**uncomplicated falciparum malaria in pregnancy - ACT
*primaquine for vivax hypnozoite is contraindicated in pregnancy
**should wait pregnancy termination
*chemoprophylaxis
**doxycycline is contraindicated
====TB in pregnancy====
*treatment
**first-line drugs cross placenta but seemingly not harmful
**
