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→Correlates of Protection
|An immune response surrogating mCoP and easily measured
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===Identifying method of CoP (mCoP)===
*Theoretically
**To measure immune responses '''at the time of exposure to the infection''' and compare them between those who get infection and not
*Practically
**To measure immune responses '''after the vaccination''' and compare them between those who get infection and not
***usually done in vaccine clinical trial phase 3
**To measure immune responses '''at the time of challenging exposure of vaccinated volunteers'''
***would be ethically approved only for milder and/or treatable infections such as seasonal influenza, cholera, dengue or cytomegalovirus
**To extrapolate vaccinated animal challenge model
**To extrapolate protective level of dosing of passive immunization (antibody treatment)
