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Correlates of Protection
Definitions of terms
| Correlates of Protection (CoP)
|
An immune response statistically correlated with protection
|
| Mechanistic CoP (mCoP)
|
An immune response responsible for protection
|
| Non-mechanistic CoP (nCoP)
|
An immune response surrogating mCoP and easily measured
|
Identifying method of CoP (mCoP)
- Theoretically
- To measure immune responses at the time of exposure to the infection and compare them between those who get infection and not
- Practically
- To measure immune responses after the vaccination and compare them between those who get infection and not
- usually done in vaccine clinical trial phase 3
- To measure immune responses at the time of challenging exposure of vaccinated volunteers
- would be ethically approved only for milder and/or treatable infections such as seasonal influenza, cholera, dengue or cytomegalovirus
- To extrapolate vaccinated animal challenge model
- To extrapolate protective level of dosing of passive immunization (antibody treatment)
Be careful
- "Immune reseponses" contain various kinds of immunological functions
- Serum antibodies with multiple isotypes and multiple functions
- Mucosal antibodies with multiple isotypes and multiple functions
- Helper T cells
- Killer T cells
- Regulatory T cells
- etc.
