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1,295 バイト追加 、 2021年5月30日 (日) 16:42
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==Definition==
*Eos. > 450/mcl
*Rare eosinophillic disorder
*Others
 
==Infectious eosinophilia==
*Helminth
**when migrating to lung
**tissue invasion
*Ectoparasites
**scabies
**myiasis
*Protozoa
**''Sarcocystis'', ''Cystoisospora belli''
*Resolving bacterial/viral infection
**"Eosinophilic dawn" - no need to investigate
*Fungus
**Coccidioidomycosis
**Paracoccidioidomycosis
*HIV?
**not by HIV itself? by superinfection?
 
==History taking==
*Where the patient stayed
**migrantの場合は必ずしも居住地での感染に限らず,移住の過程で感染する可能性もある
*Time since return in travellers
*High or moderate or mild
**mild eosinophilia may be from other than helminth
*What the patient was exposed with
**freshwater
**food, especially raw ones
**barefoot walking
*Accompanying symptoms/signs
 
==Test==
*ova in stool
*helminthのserologyは交叉反応も多く信頼性が低い
**ただし'''stronglyoides糞線虫は後の免疫抑制療法で致死的になるのでserologyでスクリーニングすべき'''
***stronglyoides serologyが陽性になったら診断を頑張るよりivermectin単回投与で治療してしまえば良い
*"hypereosinophilia" > 1500/mcL suggests tissue and organ damage
 
===Extent of eosinophilia===
*stage of infection
*duration of infection
*'''tissue invasion'''
*immune responce

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