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==risk of TB even at high CD4 count==
*CD4 cell depletion
*increase HIV replication in TB granuloma
*
==ART significantly reduces TB incidence==
==drug interaction==
*RFP induces CYP
*RFP accelerates metabolism of PI, some NNRTI and INI
==IRIS==
*major criterion
**active TB < 3 months of initiation of ART
*minor criteria
**
**
**
