HIV-TB co-infection

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2021年4月16日 (金) 16:12時点におけるVaccipedia.admin (トーク | 投稿記録)による版 (→‎IRIS)
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risk of TB even at high CD4 count

  • CD4 cell depletion
  • TB-specific T cell↓

TB exacerbates HIV infection

  • increase HIV replication in TB granuloma

ART significantly reduces TB incidence

drug interaction

  • RFP induces CYP
  • RFP accelerates metabolism of PI, some NNRTI and INI

IRIS

  • major criterion
    • active TB < 3 months of initiation of ART
  • minor criteria