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ページの作成:「==Pathogen== *''Histoplasma capsulatii'' *''Histoplasma duboisii'' in Africa *dimorphic fungus *incubation 1-4 weeks *recurrence/reactivation in years or even in decades…」
==Pathogen==
*''Histoplasma capsulatii''
*''Histoplasma duboisii'' in Africa
*dimorphic fungus
*incubation 1-4 weeks
*recurrence/reactivation in years or even in decades
*bat and birds are reservoir
**bat guano through cave exploration is at very high risk
**chicken and pigeons
==Distribution==
*US
*South East Asia
*Africa
==Clinical features==
*acute pulmonary histoplasmosis
**most common
**mostly self-limited
*chronic pulmonary histoplasmosis
**completely different form from acute ones
**COPD at risk
**fibrosing pneumoitis
**adrenal infection causing adrenal failure
**progressive to respiratory failure
*disseminated histoplasmosis
**immunocompromised at risk
**affecting multiple organs
*ocular histoplasmosis
**chronic chorio-retinitis
**controversial whether this is truly histoplamosis or not
*African histoplasmosis by ''H. duboisii''
**different clinical pictures from ''H. capsulatii''
==Diagnosis==
*culture is not so much biohazardous
==Treatment==
*basically itraconazole is the first-line
*differs depending on disease forms
*''Histoplasma capsulatii''
*''Histoplasma duboisii'' in Africa
*dimorphic fungus
*incubation 1-4 weeks
*recurrence/reactivation in years or even in decades
*bat and birds are reservoir
**bat guano through cave exploration is at very high risk
**chicken and pigeons
==Distribution==
*US
*South East Asia
*Africa
==Clinical features==
*acute pulmonary histoplasmosis
**most common
**mostly self-limited
*chronic pulmonary histoplasmosis
**completely different form from acute ones
**COPD at risk
**fibrosing pneumoitis
**adrenal infection causing adrenal failure
**progressive to respiratory failure
*disseminated histoplasmosis
**immunocompromised at risk
**affecting multiple organs
*ocular histoplasmosis
**chronic chorio-retinitis
**controversial whether this is truly histoplamosis or not
*African histoplasmosis by ''H. duboisii''
**different clinical pictures from ''H. capsulatii''
==Diagnosis==
*culture is not so much biohazardous
==Treatment==
*basically itraconazole is the first-line
*differs depending on disease forms
