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41 バイト除去 、 2021年4月27日 (火) 14:34
==clinical manifestation=====visceral leishmania===
*most serious
*same as Kala-azar
**dog, cattle is reservoir
====diagnosis of visceral leishmania====
*suspect for >2 weeks fever+splenomegaly with geographical relation
*detection of amastigote in smear of bone marrow aspiration, lymph node or spleen aspiration
====post kala-azar dermal leishmanisis (PKDL)====
*skin manifestation after completion of Tx of visceral leishmaniasis
**macular type, papular type, nodular type
**miltefosine for 12 weeks
===cutaneous leishmania===
*most common
*same as Oriental sore, Chiclero ulcer (in Latin America)
*cutaneous leishmaniasis by ''L. donovani'' is reported in Sri Lanka
====diagnosis of cutaneous leishmaniasis====
*smear of fine needle aspirate or biopsy of skin lesion
*serological test is of no use; low sensitivity and variable specificity
===mucocutaneous leishmania===
*same as Espundia, white leprosy
*lyphatic or hematogenous dissemination to mucosa in mouth and/or upper respiratory tract, resulted in destruction and deformity of nose, palate, pharynx
*secondary bacterial infection
====diagnosis of mucocutaneous leishmaniasis====
*leishmania is scarce in mucosal lesion
**strong local immune response

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