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==pathogen==
*''Clostridium tetani''
*gram positive terminal round shape (drumstick like) bacilli
*spore-forming
**drumstick looking is from spore
**means long term sustainability in soil
*strict anaerobe
*incubation 3-21 days (average 10 days)
*AB toxin
**blockade of releasing GABA in synapus
**convulsive contraction of voluntary muscles
**toxin binding is irreversible
==epidmiology==
==clinical picture==
*opisthotonus
**muscle spasm in opisthotonus is very painful
*trismus (lockjaw)
**difficulty opening mouth
*respiratory difficulties
*cardiovascular instability
**sympathetic nervous system
**drastic rise and fall of blood pressure
*localized (not generalized) tetanus also may occur
*increased muscle tones lasts more than 2 months
*muscle spasm emerges after increased muscle tones and lasts 1 month
==diagnosis==
*culture
**difficult and tricky
*PCR - toxin gene
==treatment==
==prevention==
*wound debridement is crucial
**''C. tetani'' is anaerobe which grows in closed wound area
