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→Risk factors
*malnutrition
**Tb risk inversely correlates with BMI
*....diabetes**diabetes and Tb are syndemic**diabetes and Tb pathophysiologically exacerbate each other even under treatment condition in terms of hepatotoxicity
*overcrowding
**people per room vs Tb rate per 100,000 (in Canada)
***0.4-0.6 vs 18.9
***1.0-1.2 vs 113
*....
==Natural history==
#inhalation of M.tb containing droplets
#macrophages phagocytosis
#granuloma + lymphadenopathy
#Ghon complex - primary infection
## 5% local progression/disseminated Tb
##95% latent Tb
### 10% of latent Tb reactivates in lifetime - secondary Tb
===Latent Tb===
*1/3 of the world's population have latent Tb
