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→paradoxical reaction
==Management==
===paradoxical reaction===
*inflammation after commencing Tx
*problematic in CNS, pericardial
*co-Tx with steroids
**CNS/meningitis,tuberculoma - dexamethasone
**pericardial - predonisolone
===Directoly Observed Treatment, short course (DOTs)===
*in high risk stuation
*in homeless/chaotic social circumstance
*in poor adherence/treatment failure
*Dr. Karlos Stybro
===TB in pregnancy===
*RHZE are safe
*supplementation with VitB6 (pyridoxine) recommended
**hyperemesis gravidarum
===TB in breastfeeding===
*no contraindication
*rule out TB in baby
===hepatotoxicity===
*any GI complaint may represent hepatotoxicity
*suspend all TB drugs until lab test revealed
*risk
**co-infection HIV, hepB/C
**other chronic liver disease
**alcohol
**advanced age
==Drug-resistant==
