Lymphatic filariasis

• ヒト体内でadultから生まれたmicrofilariaは吸血で蚊に移行し，蚊の体内で3回moltを繰り返してL3 larvaeに至る．

• L3は1.7mmまで体長を増し，吸血によって蚊の体外に放出され，蚊が生じた穿刺口等から皮内に侵入する

1.7mmもの体長のlarvaeがどうやって体長10mmに満たない蚊の体内で共存できるのか？

• Onchocerciasisのヒト体内の病態生理はmicrofilariaによるが，lymphatic filariasisはadultによる．

• Lymphatic filariasisでリンパ浮腫を生じている患者の下肢をエコーで観察すると，拡張したリンパ管内で蠢くadult filariaを観察できる．

Brugia malayi

Intermediate host
Category	mosquito, female
Latin	Mansonia spp. Aedes spp.
Inward infection	blood-feeding of human
Organ	midgut, thoracic muscle, proboscis
Reproduction
Course	microfilariae lose sheath migrate to thoracic muscle metamorphoses L1→L2→L3 in thoracic muscle L3 migrate to proboscis
Detection
Outward transmission	blood-feeding of human through proboscis

Paratenic host
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Definitive host
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Dead-end host
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