「Lymphatic filariasis」の版間の差分

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12行目: 12行目:
 
{{intermediate
 
{{intermediate
 
|category=mosquito, female
 
|category=mosquito, female
−
|latin=''Mansonia'' spp.<br>''Aedes'' spp.
+
|latin=''Mansonia'' spp., ''Aedes'' spp.
 
|inward=blood-feeding of human
 
|inward=blood-feeding of human
 
|organ=midgut, thoracic muscle, proboscis
 
|organ=midgut, thoracic muscle, proboscis
28行目: 28行目:
  
 
{{definitive
 
{{definitive
−
|category=human
+
|category='''HUMAN'''
 
|latin=
 
|latin=
 
|inward=blood-feeding by mosquito
 
|inward=blood-feeding by mosquito
39行目: 39行目:
 
<li>develop to adult
 
<li>develop to adult
 
*female 43-55 mm, male 13-23 mm
 
*female 43-55 mm, male 13-23 mm
−
*obstruct lymphatics resulted in elephantiasis and hydrocele in years
+
*obstruct lymphatics resulted in '''elephantiasis''' and '''hydrocele''' in years
 
<li>mate in lymphatics
 
<li>mate in lymphatics
−
<li>produce sheathed microfilariae
+
<li>produce '''sheathed microfilariae'''
 +
*177-230 µm
 
*nocturnal periodicity
 
*nocturnal periodicity
 
<li>microfilariae migrate to blood circulation
 
<li>microfilariae migrate to blood circulation
48行目: 49行目:
 
|detection=
 
|detection=
 
<ul></ul>
 
<ul></ul>
−
*microscopy, microfilariae, Giemsa stain, blood taken nocturnally
+
*'''microscopy''', '''microfilariae''', Giemsa stain, blood taken nocturnally
 +
*concentration technique
 +
**2% formalin to blood (Knott's technique)
 +
**polycarbonate membrane filtration
 +
|outward=blood-feeding by mosquito
 +
}}
 +
 
 +
==''Wuchereria bancrofti''==
 +
{{intermediate
 +
|category=mosquito, female
 +
|latin=''Aedes'' spp., ''Anopheles'' spp., ''Culex'' spp., ''Mansonia'' spp., ''Coquillettida juxtamansonia''
 +
|inward=blood-feeding of human
 +
|organ=midgut, thoracic muscle, proboscis
 +
|reproduction=
 +
|course=
 +
<ol>
 +
<li>microfilariae lose sheath
 +
<li>migrate to thoracic muscle
 +
<li>metamorphoses L1→L2→L3 in thoracic muscle
 +
<li>L3 migrate to proboscis
 +
</ol>
 +
|detection=
 +
|outward=blood-feeding of human through proboscis
 +
}}
 +
 
 +
{{definitive
 +
|category='''HUMAN'''
 +
|latin=
 +
|inward=blood-feeding by mosquito
 +
|organ=skin, lymphatics
 +
|reproduction=sexual
 +
|course=
 +
<ol>
 +
<li>L3 invade through cleavage on skin
 +
<li>L3 migrate to lymphatics
 +
<li>develop to adult
 +
*female 80-100 mm, male 40 mm
 +
*obstruct lymphatics resulted in '''elephantiasis''' and '''hydrocele''' in years
 +
<li>mate in lymphatics
 +
<li>produce '''sheathed microfilariae'''
 +
*244-296 µm
 +
*nocturnal periodicity
 +
<li>microfilariae migrate to blood circulation
 +
*mechanism unknown
 +
</ol>
 +
|detection=
 +
<ul></ul>
 +
*'''microscopy''', '''microfilariae''', Giemsa stain, blood taken nocturnally
 
*concentration technique
 
*concentration technique
 
**2% formalin to blood (Knott's technique)
 
**2% formalin to blood (Knott's technique)

2021年5月27日 (木) 00:27時点における版

  • ヒト体内でadultから生まれたmicrofilariaは吸血で蚊に移行し，蚊の体内で3回moltを繰り返してL3 larvaeに至る．
  • L3は1.7mmまで体長を増し，吸血によって蚊の体外に放出され，蚊が生じた穿刺口等から皮内に侵入する
1.7mmもの体長のlarvaeがどうやって体長10mmに満たない蚊の体内で共存できるのか？
  • Onchocerciasisのヒト体内の病態生理はmicrofilariaによるが，lymphatic filariasisはadultによる．
  • Lymphatic filariasisでリンパ浮腫を生じている患者の下肢をエコーで観察すると，拡張したリンパ管内で蠢くadult filariaを観察できる．

Brugia malayi

Intermediate host
Category mosquito, female
Latin Mansonia spp., Aedes spp.
Inward infection blood-feeding of human
Organ midgut, thoracic muscle, proboscis
Reproduction
Course
  1. microfilariae lose sheath
  2. migrate to thoracic muscle
  3. metamorphoses L1→L2→L3 in thoracic muscle
  4. L3 migrate to proboscis
Detection
Outward transmission blood-feeding of human through proboscis
Definitive host
Category HUMAN
Latin
Inward infection blood-feeding by mosquito
Organ skin, lymphatics
Reproduction sexual
Course
  1. L3 invade through cleavage on skin
  2. L3 migrate to lymphatics
  3. develop to adult
    • female 43-55 mm, male 13-23 mm
    • obstruct lymphatics resulted in elephantiasis and hydrocele in years
  4. mate in lymphatics
  5. produce sheathed microfilariae
    • 177-230 µm
    • nocturnal periodicity
  6. microfilariae migrate to blood circulation
    • mechanism unknown
Detection
    • microscopy, microfilariae, Giemsa stain, blood taken nocturnally
    • concentration technique
      • 2% formalin to blood (Knott's technique)
      • polycarbonate membrane filtration
    Outward transmission blood-feeding by mosquito

    Wuchereria bancrofti

    Intermediate host
    Category mosquito, female
    Latin Aedes spp., Anopheles spp., Culex spp., Mansonia spp., Coquillettida juxtamansonia
    Inward infection blood-feeding of human
    Organ midgut, thoracic muscle, proboscis
    Reproduction
    Course
    1. microfilariae lose sheath
    2. migrate to thoracic muscle
    3. metamorphoses L1→L2→L3 in thoracic muscle
    4. L3 migrate to proboscis
    Detection
    Outward transmission blood-feeding of human through proboscis
    Definitive host
    Category HUMAN
    Latin
    Inward infection blood-feeding by mosquito
    Organ skin, lymphatics
    Reproduction sexual
    Course
    1. L3 invade through cleavage on skin
    2. L3 migrate to lymphatics
    3. develop to adult
      • female 80-100 mm, male 40 mm
      • obstruct lymphatics resulted in elephantiasis and hydrocele in years
    4. mate in lymphatics
    5. produce sheathed microfilariae
      • 244-296 µm
      • nocturnal periodicity
    6. microfilariae migrate to blood circulation
      • mechanism unknown
    Detection
      • microscopy, microfilariae, Giemsa stain, blood taken nocturnally
      • concentration technique
        • 2% formalin to blood (Knott's technique)
        • polycarbonate membrane filtration
      Outward transmission blood-feeding by mosquito
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