「Onchocerciasis」の版間の差分

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5行目: 5行目:
 
|latin=genus ''Simulium''
 
|latin=genus ''Simulium''
 
|organ=midgut
 
|organ=midgut
 +
|inward=blood-feeding of human
 +
|reproduction=asexual
 +
|course=
 +
microfilariae has '''no sheath'''
 +
<ol>
 +
<li>migrate to thoracic muscle
 +
<li>metamorphoses L1→L2→L3 in thoracic muscle
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<li>L3 migrate to proboscis
 +
</ol>
 +
|detection=
 +
|outward=blood-feeding of human
 
}}
 
}}
  
22行目: 33行目:
 
*220-360 µm
 
*220-360 µm
 
*2 years
 
*2 years
*mainly skin, sometimes lymphatics, blood, urine
+
*mainly '''skin, connective tissue''', sometimes lymphatics, blood, urine, sputum
*
+
*allergy and inflammation resulting in serious '''skin pruritis (leopard skin, anterior tibia)''' and '''keratitis (river blindeness)'''
 +
|detection=
 +
<ul>
 +
*'''skin snipping'''
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**'''no nocturnality''', every time in a day available
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*microfilariae has no sheath
 +
</ul>
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|outward=blood-feeding by female blackfly
 
}}
 
}}
 +
 +
{{quote|content=[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC100248/ Hall LR, Pearlman E. Pathogenesis of onchocercal keratitis (river blindness). Clin Microbiol Rev. 1999;12(3):445-453. doi:10.1128/cmr.12.3.445]}}
  
 
==診断==
 
==診断==

2021年5月27日 (木) 22:59時点における版

Onchocerca volvulus

Intermediate host
Category blackfly ブヨ, female
Latin genus Simulium
Inward infection blood-feeding of human
Organ midgut
Reproduction asexual
Course microfilariae has no sheath
  1. migrate to thoracic muscle
  2. metamorphoses L1→L2→L3 in thoracic muscle
  3. L3 migrate to proboscis
Detection
Outward transmission blood-feeding of human
Definitive host
Category HUMAN
Latin
Inward infection blood-feeding by female blackfly
Organ skin, lymphatics, blood, urine
Reproduction sexual
Course
  1. L3 into adult in subcutaneous
  2. subcutaneous nodule
    • female 33-50 cm (not mm), male 2-5 cm
    • live 15 years
  3. female produce microfilariae 9 years
    • 220-360 µm
    • 2 years
    • mainly skin, connective tissue, sometimes lymphatics, blood, urine, sputum
    • allergy and inflammation resulting in serious skin pruritis (leopard skin, anterior tibia) and keratitis (river blindeness)
Detection
    • skin snipping
      • no nocturnality, every time in a day available
    • microfilariae has no sheath
Outward transmission blood-feeding by female blackfly

Hall LR, Pearlman E. Pathogenesis of onchocercal keratitis (river blindness). Clin Microbiol Rev. 1999;12(3):445-453. doi:10.1128/cmr.12.3.445

診断

  • Skin snipping による皮膚断片の培養と顕微鏡下観察
    • 高浸淫地では有用だが,低感度なので有病割合が低下すると有用性が劣る
  • RDT
    • Onchocerca vulvolsのIgG4抗体および抗原をimmunochromatographで検出

治療

  • Ivermectin