Statistical test

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2022年12月11日 (日) 23:47時点におけるVaccipedia.admin (トーク | 投稿記録)による版 (→‎Comparing Means)
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Comparing Proportions

Independent samples
(Unpaired in case of two)
Dependent samples
(Paired in case of two)
2 proportions
  • Z test
[math]\displaystyle{ \begin{align} z & = \frac{p_1-p_2}{SE_{pooled(p_1-p_2)}} \\ & = \frac{p_1-p_2}{\sqrt{\frac{\bar{p}(1-\bar{p})}{n_1}+\frac{\bar{p}(1-\bar{p})}{n_2}}} \end{align} }[/math]
≥ 3 proportions Enough large sample
  • [math]\displaystyle{ \chi^2 }[/math] test
[math]\displaystyle{ \chi^2 = \sum \frac{(O - E)^2}{E} }[/math]
[math]\displaystyle{ O }[/math] = observed values
[math]\displaystyle{ E }[/math] = expected values
  • McNemar's [math]\displaystyle{ \chi^2 }[/math] test
[math]\displaystyle{ \begin{align} & McNemar's\ \chi^2 \\ & = \frac{(n_1-n_2)^2}{n_1+n_2} \end{align} }[/math]
[math]\displaystyle{ n_i }[/math] = number of observations in discordant pair
Testing linear association
  • [math]\displaystyle{ \chi^2 }[/math] trend test
[math]\displaystyle{ \begin{align} & \chi^2 trend \\ & = \frac{(\bar{x_1}-\bar{x_2})^2}{s^2(\frac{1}{n_1}+\frac{1}{n_2})} \\ & s = \sqrt{\sum \frac{(x_i-\bar{x_i})^2}{n-1}} \end{align} }[/math]
[math]\displaystyle{ x_i }[/math] = weighted values
[math]\displaystyle{ n_i }[/math] = number of observations
≥1 cell expected value <5

Fisher's exact test

  • very rare in real researches

Comparing Means

Parametric
i.e., normally distributed
Non-parametric
i.e., not normally distributed
Independent samples
(Unpaired in case of two)
Dependent samples
(Paired in case of two)
Independent samples
(Unpaired in case of two)
Dependent samples
(Paired in case of two)
2 means

Enough large sample

  • Z test
[math]\displaystyle{ \begin{align} z & = \frac{\bar{x_1}-\bar{x_2}}{SE_{(\bar{x_1}-\bar{x_2})}} \\ & = \frac{\bar{x_1}-\bar{x_2}}{\sqrt{\frac{s_1^2}{n_1}+\frac{s_2^2}{n_2}}} \end{align} }[/math]
  • Paired Student's t test
[math]\displaystyle{ \begin{align} paired\ t & = \frac{\bar{d}}{SE_d} \\ & = \frac{\bar{d}}{\frac{s}{\sqrt{n}}} \\ \end{align} }[/math]
where [math]\displaystyle{ \bar{d} }[/math] is the mean of differences of paired observations
  • Wilcoxon rank sum test
    =Mann-Whitney test
[math]\displaystyle{ H_0 }[/math] is distribution of outcomes in both two populations are the same
  1. To rank whole combined observations of two groups
  2. To separate back the ranks into two groups
  3. To look up critical range relevant to both numbers of observations and whether the sum of ranks in the group of smaller number of observation is outside the range or not
if outside the range, p-value is smaller than designated
  • Wilcoxon signed rank test
  1. To calculate differences between pairs and discard 0 differences
  2. To rank the absolute values of differences (ignoring 0)
  3. To make sums of ranks of positive difference and ranks of negative differences
  4. To look up critical value relevant to the smaller sum of rank
here 'signed' means 'take into account signs of differences of paired data'
Small sample size <30 in a group
  • Student's t test
[math]\displaystyle{ \begin{align} t & = \frac{\bar{x_1}-\bar{x_2}}{SE_{(\bar{x_1}-\bar{x_2})}} \\ & = \frac{\bar{x_1}-\bar{x_2}}{\sqrt{\frac{(n_1-1)s_1^2+(n_2-1)s_2^2}{(n_1-1)+(n_2-1)}}\sqrt{\frac{1}{n_1}+\frac{1}{n_2}}} \end{align} }[/math]
Large discrepancy in SDs between groups
  • Bootstrap
  • Non-parametric
  • Fisher-Behrens
  • Welch
≥ 3 means
  • One-way ANOVA
  • Linear-regression model
  • Repeated measures ANOVA
  • Kruskall-Wallis test
[math]\displaystyle{ H_0 }[/math] is distribution of outcomes in all populations are the same
  1. To rank whole combined observations of all groups
  2. To separate back the ranks into original groups
  3. To make sum of ranks in each group
[math]\displaystyle{ H = \frac{n-1}{n} \sum_{i=1}^k \frac{n_i(\bar{R}-E_R)}{s^2} }[/math]
[math]\displaystyle{ H }[/math] is Kruskal-Wallis statistics
[math]\displaystyle{ n_i }[/math] is number of observations in group [math]\displaystyle{ i }[/math]
[math]\displaystyle{ \bar{R} }[/math] is the mean of rank sum in group [math]\displaystyle{ i }[/math]
[math]\displaystyle{ E_R }[/math] is expected value of the rankings
[math]\displaystyle{ s^2 }[/math] is the variance of rank
To look up critical values relevant to sum of ranks in the group of smaller number of observation

*needs try to transform data into parametric (e.g., logarithmic), or other considerations