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*Katsurada Fujiro found 26 May 1904 from a cat in Yamanashi（水腫腸満）
*Fujinami Kan found 30 May 1904 from a murder victim in Katayama, Hiroshima（片山病）
*found ova egg in 1904 in Saga（奇病）
==pathogenesis==
*ova produced adult female paired by female adult within male migrate to messenteric vein from portal vein and lay eggs into messenteric venule, which are secreted from messenteric venule to intestinal lumen*eggs also reach urinary bladder or genital tract and generate inflammation, followed by necrosis of tissue and perforation to intestine, resulted in extracorporeal distribution of ova egg via stool*eggs are also distributed in liver and cause inflammation resulting in cirrhosis*inflammation is exclusively due to ovaegg
*'''adult pairs do not cause disease per se'''
==treatment==
*praziquantel was discovered only in mid-1970s in Germany
==control==
*only way to control is eliminate intermediate hosts, snails
