Measles
ナビゲーションに移動
検索に移動
| Navigation Menu | 
|
| 展開するGeneral issues of Vaccine |
|---|
| 展開するGeneral issues of Tropical med. |
|---|
| 展開するGeneral issues of Travel med. |
|---|
| 展開するImmunology |
|---|
| 展開するEpi & Stats |
|---|
| 展開するVirus |
|---|
| 展開するCOVID-19 |
|---|
| 展開するBacteria |
|---|
| 展開するRickettsia |
|---|
| 展開するProtozoa |
|---|
| 展開するFungi |
|---|
| 展開するNematode (roundworm) |
|---|
| 展開するTrematode (fluke, distoma) |
|---|
| 展開するCestode (tapeworm) |
|---|
| 展開するMedical Zoology |
|---|
目次
history
- 1970-80s sub-Saharan children mortality &50%, majority of which owing to measles
- 1880s devastating measles outbreak in Fiji introduced by foreign ships resulted in 20-30% of Fijian population died from measles
complications
- acute phase death directly due to viral damage
- black-pigmented rashes
- blindness by measles accompanied by vitamin A deficiency
- ketatitis
- immune paralysis
relation with malnutrition
- still controversial, malnutrition first or measles first
risk for death from measles
- vit. A deficiency
- malnutrition - causation controversial
- in larger outbreak
- in larger household contact
- younger children
- HIV positive children
etiology of child death
- acute overwhelming infection in the first week
- secondary bacterial pneumonia in the second week
- S. pneumoniae
- S. aureus
- air trapping is a feature - possible pneumothorax
- secondary viral infection
- HSV
- RSV
- adenovirus
- post-measles syndrome
- malnutrition
- immune paralysis, immunomodulation
strategies to control
- isolation, theoretically good but useless in reality
- effective treatment with vit. A and antimicrobials
- vit. A and antimicrobials for secondary bacterial infection can reduce mortality
- vaccination
- maternal passive immunity wane in 6-9 months after birth
- rational for the first vaccination after 9 months of age
- 10% of primary vaccine failure in the first vaccination
- rational for the second vaccination
- maternal passive immunity wane in 6-9 months after birth
