Talaromycosis

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Pathogen

• Talaromyces marneffei
  • formaly Penicillium
• habitat unknown
• bamboo rats reservoir
• dimorphic fungus
  • binary fission in yeast form differently from other yeasts

Distribution

• China
• SE Asia

Clinical features

• pulmonary
• disseminated
• cellular immunocompromised at risk
• relapse highly
• very characteristic skin lesions
  • disseminated nodules in face and trunk, umblicated and later developing eschars
  • contains Talaromyces

Diagnosis

• high sensitivity of blood culture
  • red pigmentation of agar around fungus on petri dish

Treatment

• AMPH-B, azoles
• poor prognosis