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==clinical features=====latent TB===
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==epidemiology==
*1.2 mil. (~10%) of 10 mil. new cases/year are under 15 y/o in 2019
*low education for parents/care givers
*80-90% of children cases
*no symptoms
*Mantaux Mantoux test
**IGRA is often unavailable in LMIC
*R+H for 3 months
==clinical TB==
*often paucibacillary, difficult to diagnose
**false negative culture
===pulmonary TB===
*75% (60-80%) of clinical TB
*<2 y/o symptoms are very uncommon
**fever, weight loss, cough, anorexia, diarrhea
*hilar adenopathy on CXR is very common
*gastric aspiration when sputum unavailable
===extrapulmonary TB===
*peripheral lymphadenitis TB counts for 50-60% of extrapulmonary TB in DRC
**anterior cervical, submandibular, supraclavicular
**painless, without inflammation, fistulation
*TB pericardial effusion
**rare but possible
**right-side heart failure
*bone/joint TB
**large weightbearing bones/joints
***Pott's diesase
***cold abscess beside vertebra
***gibbus deformity
*abd TB
**rare in children
*TB meningitis
**common in <2 y/o
**BCG provides protection
**no specific symptoms
***fever, anorexia, weight loss,
**30% mortality
*miliary TB
**most common in <2 y/o
**high fever, weight loss, respiratory distress,
===treatment of clinical TB===
*H+R+Z+E
*every morning 2 hours before eating
*H 10 mg/kg/d
*R 15 mg/kg/d
*Z 25-30 mg/kg/d
*E 20-25 mg/kg/d
