Plague

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history

• Justinian plague
  • possibly from Africa
• Black death
  • from Asia
• 19th century pandemic
  • from China through Hong Kong

pathogen

• Yersinia pestis
• gram negative bacili ("cocco-bacilli")
• sylvatic plague
  • wide range of wild rodents, rabbits, squirrels, etc.
• urban plague
  • black rat Rattus rattus

clinical features

• "bubo" - prominent lymphadenopathy
  • very much painful
• incubation 2-7 days after flea bites or close contact to contaminated animal secrete
• bubonic plague
• septicemic plague
  • meningitis may occur
• pneumonic plague