Vaccines for Asplenia

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UPDATE HISTORY

• This page was created at 15th Feb 2023

Vaccines specifically recommended for asplenia

Haemophillus influenzae type b (Hib) vaccine

Pneumococcal vaccines

Meningococcal vaccines

Interaction between meningococcal and pneumococcal conjugate vaccine

See Interactions of MenACWY conjugate vaccines and other vaccines

Immunization schedules for asplenia

※NOTICE

• The following descriptions are based on Official Routine Immunization Schedules in Japan as well as vaccines approvement in Japan.
• Catch-up schedules not covered by Official Schedules in Japan are derived from ACIP recommendations for Altered Immunocompetence and Catch-up Immunization Schedule for Children and Adolescents Who Start Late or Who Are More than 1 Month Behind (both accessed on 15th Feb 2023).

Catch-up schedules for asplenia with unimmunized for each of vaccine

Age	Hib if unimmunized	Pneumococcal if unimmunized	Meningococcal if unimmunized	Age
years < 1	3-4 Hib as Official Routine Schedules	3-4 PCV13 as Official Routine Schedules PPSV23: wait until ≥ 2 years old	Wait until ≥ 2 years old consider unapproved imported MenACWY-CRM	years < 1
1 ≤ years < 2	2 Hib [0, 8w] of which 1 dose as Official Catch-up Schedules	2 PCV13 [0, 60d] as Official Routine Schedules PPSV23: wait until ≥ 2 years old		1 ≤ years < 2
2 ≤ years < 5	2 Hib [0, 8w]	2 PCV13 [0, 8w] of which 1 dose as Official Catch-up Schedules if PPSV23 precedes, 1 year after the precedent PPSV23 2 PPSV23 [0, 5y] 8 weeks after the last PCV13	2 Men-ACWY [0, 8w] メナクトラ Menactra exclusively 4 weeks after PCV13 メンクアッドフィ MenQuadfi can be co-administered with PCV13	2 ≤ years < 5
5 ≤ years < 6	1 Hib	1 PCV13 as Official Catch-up Schedules if PPSV23 precedes, 1 year after the precedent PPSV23 2 PPSV23 [0, 5y] 8 weeks after the last PCV13		5 ≤ years < 6
6 ≤ years <10		1 PCV13 if PPSV23 precedes, 1 year after the precedent PPSV23 2 PPSV23 [0, 5y] 8 weeks after the last PCV13		6 ≤ years <10
10 ≤ years			2 Men-ACWY [0, 8w] メナクトラ Menactra exclusively 4 weeks after PCV13 メンクアッドフィ MenQuadfi can be co-administered with PCV13 consider unapproved imported Men-B	10 ≤ years

Before a scheduled splenectomy

Post-splenectomy and congenital asplenia