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NRTI + NRTI + {NNRTI or INI or PI}
===scheme===
{|class="wikitable" style="width:1200px"
|-
!colspan="4"|NRTI Nucleoside Reverse Transcriptase Inhibitor
|-
!style="width:25%"|Tenofovir<br>TDF
|style="width:25%"
*Once daily
*well tolerated
|style="width:25%" rowspan="2"|
*effective for Hep B
|style="width:25%" rowspan="2"|
*Renal toxicity (tubular damage)
**Fanconi syndrome
**hypophosphataemia
**glucosuria
**proteinuria
*Osteoporosis
Less side effects in TAF
|-
!Tenofovir alafenamide fumarate<br>TAF
|
*prodrug of tenofovir
|-
!Lamivudine<br>3TC
|rowspan="2"|
*backbone for all regimens
*well tolerated
|rowspan="2"|
*effective for Hep B
|
|-
!Emtricitabine<br>FTC
|-
!Zidovudine<br>AZT
|
*Twice daily
*well tolerated
*the world-first anti-HIV
|
|
*macrocytic anemia
*lipodystrophy
|}
===NRTIs===
