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General issues of Vaccine
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General issues of Tropical med.
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General issues of Travel med.
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Trematode (fluke, distoma)
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Three mechanisms (assumptions) of data missing
Mechanisms (assumptions) of data missing
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Abbr.
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Does missing depend on...
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[Example] A cohort study in which participants self report their body weight every week via special app installed on their smartphones for 52 weeks in total
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missing value itself?
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other observed variable(s)?
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Missing not at random
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MNAR
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YES
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- Some participants intentionally deny to report higher body weights they don't like and only report lower body weights they like
- Data of those participants are missed because of the values in the variable body weight themselves
- Researchers cannot explain/predict the missing mechanism by
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Missing at randam
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MAR
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NO
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YES
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- 15% of female participants denied to report their body weights after the agreement regardless of measured body weights, but only 1% of male denied to report:
- Unobserved (missing, unrepoted) values in the variable body weight themselves did not affect the missing, but another variable sex can explain the reason of missing
- Missing mechanism is at random, i.e., free from unobserved (missing) values only inside each participant
- Missing mechanism is NOT at random, i.e., NOT free from another variable sex; missing occurred depending on the values in the variable sex
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Missing completely at random
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MCAR
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NO
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NO
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- A participant moved to outside cohort area because of family affair which has nothing to do with the study and is lost to follow up after the 10th week
- A participant fails to report body weights because of malfunction of the app between the 15th and 17th weeks
- The reasons (mechanisms) of missing have nothing to do with other observed (certainly reported) values, values in other variables, nor unobserved (missing) values themselves
- Missing mechanism is completely at random, i.e., completely free from either of observed values or unobserved (missing) values
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