Meningococcus

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pathogen

• Neisseria meningitidis
• gram negative diplococci
• carriage in nasopharynx
• 12 identified capsular serogroups
• common pathogenic serogroup A, B, C, W, X, Y
• seasonal epidemics by group A, C
  • meningitis belt
• sporadic cases by e.g. group B
  • Latin America
  • Norway
  • New Zealand
• immunity generated by polysaccharide capsule except B
  • may be the reason that herd immunity development relatively slow and sporadic outbreaks continue in above countries

epidemiology

• highest < 2 y/o and adolescent
• annual outbreak during dry season in meningitis belt
  • dry winds make people's nose drier resulting in easier capture and membrane breakthrough
• wide range difference of nasopharynx carriage between countries
  • reason totally unknown
  • NZ & 3%
  • Nigeria muslim boarding school 30-40%
• 日本で戦後急速に発生が減ったのは，抗菌薬の導入普及と発熱早期での過剰投与，および住宅環境の改善による小児の集蔟が減少したためかもしれない

transmission

• aerosol
• fomite
• adolescent activity

clinical picture

• fever
• distinctive petechiae anywhere in whole body
  • apparent pain accompanies with petechia in contrast to dengue
  • in earlier stage rashes are inflammation, not petechiae
• no fading by pressure with glass tumbler - "tumbler test"
• resulting in purple bruising of skin
• photophobia
• headache, neck stiffness, vomiting
• irritability and/or confusion

vaccine

development history

• 1960s - purified PS vaccines for A and C
  • immunity short term due to lack of T-cell involvement
• 1990s - conjugated vaccines for A and C after success of Hib conjugate vaccine
• 2000s - monovalent A vaccine for Africa
  • "MenAfriVac"

current vaccines

• A polysaccharide
  • MenAfriVac
• C conjugate
• A,C,Y,W135 conjugate
  • Menactra (Sanofi Pasteur)
  • Menveo (GSK)
  • Nimenrix (Pfizer)
• B protein (not polysaccharide)
  • Bexsero (GSK)
  • Trumenba (Pfizer)
  • VA-MENGOC-BC (Finlay Institute of Cuba)

issues of men B vaccine

• polysaccharide of B is relatively low immunogenic
  • the reason is considered because of interaction between B polysaccharide and fetal brain tissue, resulting in possible immunotolerance
    • interaction is observed as antibodies against B-PS have also affinity to fetal brain tissue
  • it means B-PS vaccine has potential of neurological damage for young infants
• currently available men B vaccines are protein-based vaccine, not PS vaccine
  • proteins expressed on the surface of N. meningitidis group B are purified through bacterial culture

Interactions of MenACWY conjugate vaccines and other vaccines

	MenACWY-DT	MenACWY-TT
	メナクトラ Menactra	メンクアッドフィ MenQuadfi
PCV7	At clinical trial of Menactra Doses at 9 and 12 months of age Concomitant dose with PCV7 at 12 months showed unmet non-inferiority criteria in 3 pneumococcal serotypes out of 7 in PCV7
PCV13
DTaP