HIV-TB co-infection

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risk of TB even at high CD4 count

• CD4 cell depletion
• TB-specific T cell↓

TB exacerbates HIV infection

• increase HIV replication in TB granuloma

drug interaction

• RFP induces CYP
• RFP accelerates metabolism of PI, some NNRTI and INI

IRIS

• major criterion
  • active TB < 3 months of initiation of ART
• minor criteria