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→pathogen
*gram negative cocco-bacilli
*facultative intracellular bacteria
**prefers macrophage and reticuloendothelial system cells***reason why brucellosis shows undulating long period course as well as potential of relapse**also infectable in various cells including bones and joints
==epidemiology==
*estimated > 500,000 human cases per year
==clinical features==
*depressive, anorexic, lethargy
*hepatosplenomegaly
*septic arthritis
*muscle abscess - psoas etc.
*orchitis
*low grade meningoencephalitis
*endocarditis (1%)
===difference in spp.===
*''B. abortus''
**insidious slow onset
**axial skelton
*''B. melitensis''
**acute onset
**peripheral joints
**single joint in children
*''B. suis''
**acute onset
**deep tissue abscess
==diagnosis==
*blood culture**in short time to 3 weeks**quite low sensitivity*bone marrow culture more sensitive*standard agglutination test (SAT)*microagglutination test (MAT)
==treatment==
*relapse possible
*combination of 2 antibiotics for 3 months needed
*doxycycline + gentamycin/rifampcin
==prevention==
*one health approach
*pasteurization of milk
*animal vaccination
