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==poliovirus==
*family ''Picornaviridae'', genus ''Enterovirus''
**Human enterovirus A, B, C, D
***PV belongs to HEV-C
***EV71 belongs to HEV-A
***EV68 (EV-D68) belongs to HEV-D
*non-enveloped single stranded positive sense RNA virus
**4 capsid proteins
*3 serotypes
**wPV2 already eradicated in 2015
==VDPV==
*cVDPV1 and cVDPV2 are endemic in Africa and Southeast Asia as well as in Pakistan and Afghanistan
**in recent 12 months no local transmission in Southeast Asia
*cVDPV3 is not identified so far
*VDPV is relatively physically stable in environment but cannot keep infectivity not for long time, thus continuous detection of VDPV in enviromnent means continuous transmission and/or excretion of VDPV from people living in the community
*distribution of breech (disinfectant) and/or irradication ultraviolet light may be effective against PV/VDPV
*threshold of immunization coverage to maintain PV/VDPV free is 85-90%
==Global Polio Eradication
*strategies
**extensive immunization with OPV or IPV
**surveillance of acute flaccid paralysis
**lab diagnosis
*AFP cases and true poliovirus infection overlap very little
**⇔Variola cases and true smallpox infection overlapped almost identically
*novel OPV2
**using genetically modified stain
**more stabilized genomically
==clinical==
*mostly asymptomatic
*many mild manifestation
*polio paralytic cases 79% by wPV1, 8% by wPV2, 13% by wPV3 in 2010
